Editors choice

Best Quercetin Supplements for Immune Support and Inflammation Relief

Best Quercetin Supplements for Immune Support and Inflammation Relief

Dr. Jason Hale

Saturday, March 8, 2025

7 min read

Afifiliate disclosure*

You may not feel it yet, but the damage is already being done.

Swelling. Oxidative stress. Rising blood sugar. Silent changes in your heart and cells that can lead to serious disease.

There’s a Silent Killer Lurking in You

It’s not always obvious. There’s no sudden pain, no dramatic symptoms. But slowly, silently, oxidative stress and chronic inflammation begin to erode your health from the inside out.

They stiffen your arteries.

They spike your blood sugar.

They damage DNA and give abnormal cells a chance to grow.

This is how heart disease begins – not with sudden symptoms, but with years of unchecked cellular stress. It’s how cancer finds its opening. It’s how energy fades, metabolism stalls, and aging accelerates.

And the worst part? Most people never know it’s happening, until it’s too late.

How Quercetin Provides Relief

Quercetin works where it matters most: calming inflammation, fighting oxidative stress, and protecting your cells from long-term damage.

It helps shut down key triggers that cause swelling, joint pain, and artery damage, while acting as a powerful antioxidant to neutralize the unstable molecules that age your body and turn cholesterol into plaque.

It also supports heart health and blood sugar control by improving circulation, lowering blood pressure, and helping your body respond better to insulin.

Most importantly, quercetin helps your body repair healthy cells and clear out damaged ones, a key reason it’s being studied for cancer prevention.

However, not every quercetin supplement is created equal.

100+

Exceptional Purity: PartiQlar’s quercetin is exceptionally pure, hitting the 98% mark, verified by third-party labs.

Decent Value: The premium-quality supplement comes at an affordable price, outperforming every competitor.

Single-Ingredient Formulation: The Pure Quercetin is a highly-focused, single-ingredient supplement, made with high-quality ingredients.

Proven Effectiveness: PartiQlar’s supplement has proven to be the most effective in our live trial.

100+

Exceptional Purity: PartiQlar’s quercetin is exceptionally pure, hitting the 98% mark, verified by third-party labs.

Decent Value: The premium-quality supplement comes at an affordable price, outperforming every competitor.

Single-Ingredient Formulation: The Pure Quercetin is a highly-focused, single-ingredient supplement, made with high-quality ingredients.

Proven Effectiveness: PartiQlar’s supplement has proven to be the most effective in our live trial.

100+

Exceptional Purity: PartiQlar’s quercetin is exceptionally pure, hitting the 98% mark, verified by third-party labs.

Decent Value: The premium-quality supplement comes at an affordable price, outperforming every competitor.

Single-Ingredient Formulation: The Pure Quercetin is a highly-focused, single-ingredient supplement, made with high-quality ingredients.

Proven Effectiveness: PartiQlar’s supplement has proven to be the most effective in our live trial.

About The Author – Dr. Jason Hale

Dr. Jason Hale is a veteran researcher specializing in sports and longevity supplements. As Editor-in-Chief of The Wellness Journal, he leverages his industry connections to lead in-depth product studies and deliver science-backed insights.

The Best Quercetin Supplements in 2025 – Peer-Reviewed

At The Wellness Journal, we sent today’s leading quercetin supplements to an independent, CLIA-certified lab for purity and potency analysis. Full lab reports are available on request.

Products that passed our first screen for purity, transparency, and value were put through a second round of review led by clinical pharmacologist Dr. Adrian Voss, PhD.

Below you’ll find our final rankings, each with a concise lab-note snapshot, so you can identify the clear winner in seconds.

Products that passed our first screen for purity, transparency, and value were put through a second round of review led by clinical pharmacologist Dr. Adrian Voss, PhD.

Below you’ll find our final rankings, each with a concise lab-note snapshot, so you can identify the clear winner in seconds.

1. Pure Quercetin by partiQlar- A+

1. Pure Quercetin by partiQlar- A+

Third-Party Tested: Each batch of partiQlar’s quercetin is backed by a Certificate of Analysis, confirming the 98% purity.

Highly Potent: The quercetin is dosed at a very reasonable 500 mg/capsule, which is clinically proven to be safe & potent.

Proven Effectiveness: This quercetin has been the most successful one in our study – the blood markers of our users have improved drastically.

Why It’s The Best Option

PartiQlar’s Pure Quercetin delivers science-backed potency in its simplest, most focused form. Each capsule contains 500 mg of quercetin at an exceptional 98% purity, confirmed by third-party laboratories through a Certificate of Analysis. This high-dose, single-ingredient formulation ensures users get only the purest quercetin, without unnecessary fillers or additives.

Each capsule delivers 500 mg of >98% pure quercetin, lab-verified and free from fillers. This single-ingredient formula keeps it simple and clinically focused.

In our comparative study, partiQlar’s quercetin consistently led the pack, showing the most significant improvements in user blood markers tied to inflammation and immune function. Users also reported noticeable boosts in daily energy and resilience, underscoring the supplement’s practical effectiveness alongside its clinical credentials.

In our study, partiQlar outperformed every other brand in key blood markers tied to inflammation and immune health. Participants also reported better daily energy and resilience.

Despite its purity and performance, it’s priced lower than many competitors, making it the strongest value on the market.

Despite its premium quality and proven results, partiQlar’s quercetin remains affordably priced, offering unmatched value compared to competitors. For those seeking a high-purity, research-backed quercetin supplement that delivers real-world benefits, partiQlar stands out as the clear leader.

Lab Notes

Purity Verified – Independent lab confirms > 98 % quercetin and zero fillers, heavy metals, or microbial issues.

Label-Accuracy Check – Capsule weighed in at 502 mg of active quercetin; matches what’s on the bottle.

Superior Absorption – The absorption material drove quercetin levels in mice to roughly twenty-times higher than plain powder in our test panel.

Verdict: Best overall performance and value in the lineup.

Pros

Low price for a premium-quality supplement.

Highly-pure, with 3rd-party certification as proof.

Single-ingredient, additive-free formula.

Well-measured clinical dose (500 mg).

Pros

Low price for a premium-quality supplement.

Highly-pure, with 3rd-party certification as proof.

Single-ingredient, additive-free formula.

Well-measured clinical dose (500 mg).

Pros

Low price for a premium-quality supplement.

Highly-pure, with 3rd-party certification as proof.

Single-ingredient, additive-free formula.

Well-measured clinical dose (500 mg).

Cons

Tends to run out of stock fast due to high demand.

Cons

Tends to run out of stock fast due to high demand.

Cons

Tends to run out of stock fast due to high demand.

SPECIAL OFFER ALERT: use code WELLNESS15 for -15% off all partiQlar supplements

SPECIAL OFFER ALERT: use code WELLNESS15 for -15% off all partiQlar supplements

SPECIAL OFFER ALERT: use code WELLNESS15 for -15% off all partiQlar supplements

The Voice Of The People

📣 We looked through customer reviews from across the internet to see what people really think about this brand. Here’s what they had to say:

“Been having problems with high blood pressure since my late 40s. A doctor recommended quercetin, so I started taking partiQlar’s Pure Quercetin. It started working gradually, and now my blood pressure readings, while somewhat high, aren’t as extreme as they used to be.”

The Voice Of The People

📣 We looked through customer reviews from across the internet to see what people really think about this brand. Here’s what they had to say:

“Been having problems with high blood pressure since my late 40s. A doctor recommended quercetin, so I started taking partiQlar’s Pure Quercetin. It started working gradually, and now my blood pressure readings, while somewhat high, aren’t as extreme as they used to be.”

The Voice Of The People

📣 We looked through customer reviews from across the internet to see what people really think about this brand. Here’s what they had to say:

“Been having problems with high blood pressure since my late 40s. A doctor recommended quercetin, so I started taking partiQlar’s Pure Quercetin. It started working gradually, and now my blood pressure readings, while somewhat high, aren’t as extreme as they used to be.”

2. Quercetin / Bromelain Complex by prohealth - B+

2. Quercetin / Bromelain Complex by prohealth - B+

Decent Purity: Prohealth provides a 95%+ pure product, backed by a legitimate Certificate of Analysis. 

Supplement Blend: This supplement is a blend of quercetin, vitamin C, bromelain, and magnesium. 

Potentially Overdosed: Prohealth’s product exceeds the daily value of vitamin C by 6+ times, and uses a 1000 mg dose of quercetin, which could cause side effects.

Why It’s a Strong Contender:

ProHealth’s Quercetin Bromelain Complex delivers 1,000 mg of quercetin, 500 mg of bromelain, and 1,000 mg of vitamin C per 3-tablet serving. While the addition of bromelain supports absorption, the formula relies on very high doses rather than optimized delivery.

This formula combines 1,000 mg of quercetin with bromelain and high-dose vitamin C, but leans on quantity over optimized delivery.

Most studies show benefits at around 500 mg of quercetin daily, making ProHealth’s dose unnecessarily high for most users, with a higher risk of side effects like headaches or digestive upset. The vitamin C content also exceeds the daily value by over six times, offering little extra benefit and potential downsides for some.

Most clinical benefits appear around 500 mg/day. Prohealth doubles that, increasing the risk of headaches or gut issues without clear added benefit. Its vitamin C dose also far exceeds daily needs.

Overall, this is an aggressive, older-school formulation that may suit users seeking high-intensity support, but more modern quercetin supplements now offer better absorption with lower, safer doses.

It’s a heavy-handed, older-style supplement that may appeal to users chasing intensity, but today’s better-formulated options deliver results with less strain on the system.

Lab Notes

Purity Check – Lab confirms > 95 % quercetin content; bromelain and vitamin C match label specs.

Dose & Blend – Delivers a very large 1,000 mg quercetin plus 500 mg bromelain and high-dose vitamin C in one serving. Bromelain aids absorption, but the overall formula relies on shear quantity rather than modern delivery tech.

Tolerance Findings – A few mice exerted signs of nausea as a side effect of the supplement.

Verdict: Solid purity, but an old-school “megadose” approach.

Lab Notes

Purity Check – Lab confirms > 95 % quercetin content; bromelain and vitamin C match label specs.

Dose & Blend – Delivers a very large 1,000 mg quercetin plus 500 mg bromelain and high-dose vitamin C in one serving. Bromelain aids absorption, but the overall formula relies on shear quantity rather than modern delivery tech.

Tolerance Findings – A few mice exerted signs of nausea as a side effect of the supplement.

Verdict: Solid purity, but an old-school “megadose” approach.

Pros

High-strength doses may appeal to users seeking aggressive support.

Includes bromelain to aid quercetin absorption.

Also provides vitamin C and magnesium for added immune support.

Pros

High-strength doses may appeal to users seeking aggressive support.

Includes bromelain to aid quercetin absorption.

Also provides vitamin C and magnesium for added immune support.

Pros

High-strength doses may appeal to users seeking aggressive support.

Includes bromelain to aid quercetin absorption.

Also provides vitamin C and magnesium for added immune support.

Cons

Overdosed quercetin and vitamin C may increase side effect risk.

Lacks advanced delivery forms (like liposomal or phytosome) for optimized absorption.

Cons

Overdosed quercetin and vitamin C may increase side effect risk.

Lacks advanced delivery forms (like liposomal or phytosome) for optimized absorption.

Cons

Overdosed quercetin and vitamin C may increase side effect risk.

Lacks advanced delivery forms (like liposomal or phytosome) for optimized absorption.

  1. Pure Quercetin by DoNotAge - B

  1. Pure Quercetin by DoNotAge - B

Highly Pure: DoNotAge’s Pure Quercetin is 99% pure, the claim being backed by third-party laboratories.

Single-Ingredient Focus: Nothing but quercetin dihydrate, which is perfect for those looking to take a filler-free supplement.

Moderate Dosage: DoNotAge offers a 400 mg dose per capsule, which is a modest dose compared to some competitors.

DoNotAge’s formula emphasizes purity and simplicity. At 400 mg per capsule, it hits the lower end of effective dosing (studies often use 500 mg/day0, so users seeking stronger support may need to take multiple capsules. It lacks absorption enhancers like bromelain or phytosome delivery systems, which modern formulations use to boost bioavailability.

With 400 mg of >99% pure quercetin per capsule, this formula focuses on simplicity and control, but stays at the low end of effective dosing.

It’s free from fillers and extras, but also lacks any absorption enhancers, which limits its bioavailability compared to newer delivery systems.

Overall, this is a clean, no-nonsense option for users who value maximum purity and prefer to control their dosing. However, those looking for advanced absorption or higher single-serving potency may find it underpowered compared to more sophisticated blends.

A solid pick for purity-focused users who prefer to stack or adjust their dose, but for those seeking stronger, more efficient effects, it may fall short.

Lab Notes

Purity Verified – Independent lab shows 99 % quercetin with zero fillers or contaminants.

Absorption Limitation – No bromelain, liposomal, or phytosome aid; rodent blood tests showed only moderate uptake compared to enhanced formulas.

Tolerance – Clean profile; no digestive issues even at two-capsule (800 mg) daily use.

Verdict: Excellent purity, yet held back by average absorption and a modest per-capsule dose. 

Pros

Ultra-high purity (>99%) with transparent lab testing.

Simple, single-ingredient formula: easy to stack or adjust dosage.

Flexible dosing lets users tailor intake to their needs.

Pros

Ultra-high purity (>99%) with transparent lab testing.

Simple, single-ingredient formula: easy to stack or adjust dosage.

Flexible dosing lets users tailor intake to their needs.

Pros

Ultra-high purity (>99%) with transparent lab testing.

Simple, single-ingredient formula: easy to stack or adjust dosage.

Flexible dosing lets users tailor intake to their needs.

Cons

No natural absorption enhancers (e.g., bromelain, phytosomes).

Lower per-capsule dose may require multiple capsules to reach clinically studied levels.

Cons

No natural absorption enhancers.

Lower per-capsule dose.

Cons

No natural absorption enhancers (e.g., bromelain, phytosomes).

Lower per-capsule dose may require multiple capsules to reach clinically studied levels.

  1. Quercetin Phytosome by Thorne - B

  1. Quercetin Phytosome by Thorne - B

Enhanced Absorption: Uses a proprietary phytosome complex (quercetin bound to sunflower phospholipids) for better bioavailability.

Underpowered Dose: At just 250 mg per capsule, you’ll need multiple pills to reach the 500 mg/day commonly used in studies.

Single-Ingredient Precision: Contains only quercetin phytosome: no fillers or extra actives.

Thorne’s formula prioritizes delivery technology over high-dose strength. Its phytosome complex does boost absorption, but you’ll need two to three capsules daily to match clinical dosing, which adds up in both cost and pill burden.

Thorne uses a phytosome delivery system to boost absorption, but each capsule only contains 250 mg, which is well below clinical dosing. 

This product comes in a 60-capsule bottle, so at three capsules per day you’re looking at just a 20-day supply: far shorter than most 30- or 60-day designs from competitors. Such under-dosage significantly reduces the value as well, because the product costs $42. 

To match effective levels, you’ll need 2–3 capsules daily, shrinking a 60-count bottle to just 20 days.

Overall, Thorne’s Phytosome stands out for modern delivery and Thorne’s solid reputation. However, its low per-capsule potency and premium price point make it less competitive than brands offering clinical-strength quercetin in fewer pills.

At $42 per bottle, the cost-per-effective-dose adds up fast. While the delivery tech and brand reputation are solid, the low potency and short supply make it less compelling than higher-strength, better-value options.

Lab Notes

Absorption Tech Verified – Blood testing confirms the phytosome carrier delivers quercetin levels about 5-6× higher than plain powder.

Dose Limitation – Each capsule provides only 250 mg, which proved to be less effective during blood tests of the rodents.

Clean Formula – No fillers or added stimulants; sunflower-based phospholipids are well-tolerated.

Verdict: Solid absorption, but low potency makes it a less practical supplement.

Combined with a premium price tag, this limits its appeal for those seeking a focused, high-dose glutathione supplement.

Pros

Phytosome tech boosts quercetin absorption.

Pure, filler-free formula.

Pros

Phytosome tech boosts quercetin absorption.

Pure, filler-free formula.

Pros

Phytosome tech boosts quercetin absorption.

Pure, filler-free formula.

Cons

Only 250 mg per capsule, multiple pills needed.

60 capsules last ~20 days at study doses.

Higher cost per effective dose.

Cons

Only 250 mg per capsule, multiple pills needed.

60 capsules last ~20 days at study doses.

Higher cost per effective dose.

Cons

Only 250 mg per capsule, multiple pills needed.

60 capsules last ~20 days at study doses.

Higher cost per effective dose.

100+

Exceptional Purity: PartiQlar’s quercetin is exceptionally pure, hitting the 98% mark, verified by third-party labs.

Decent Value: The premium-quality supplement comes at an affordable price, outperforming every competitor.

Single-Ingredient Formulation: The Pure Quercetin is a highly-focused, single-ingredient supplement, made with high-quality ingredients.

Proven Effectiveness: PartiQlar’s supplement has proven to be the most effective in our live trial.

100+

Exceptional Purity: PartiQlar’s quercetin is exceptionally pure, hitting the 98% mark, verified by third-party labs.

Decent Value: The premium-quality supplement comes at an affordable price, outperforming every competitor.

Single-Ingredient Formulation: The Pure Quercetin is a highly-focused, single-ingredient supplement, made with high-quality ingredients.

Proven Effectiveness: PartiQlar’s supplement has proven to be the most effective in our live trial.

100+

Exceptional Purity: PartiQlar’s quercetin is exceptionally pure, hitting the 98% mark, verified by third-party labs.

Decent Value: The premium-quality supplement comes at an affordable price, outperforming every competitor.

Single-Ingredient Formulation: The Pure Quercetin is a highly-focused, single-ingredient supplement, made with high-quality ingredients.

Proven Effectiveness: PartiQlar’s supplement has proven to be the most effective in our live trial.

How To Choose The Right Quercetin Supplement

How To Choose The Right Quercetin Supplement

How to Choose the Right Quercetin Supplement

The best quercetin supplements do three things:

  1. They absorb well.

  1. They deliver a clinically effective dose.

  1. And they’re proven clean and potent by third-party labs.

That’s critical, because if quercetin doesn’t reach your bloodstream, it can’t fight the inflammation, oxidative stress, or cellular damage that silently threatens your heart, blood sugar, and long-term health.

Few supplements meet all three standards. PartiQlar does: with 500 mg of enhanced quercetin and >98% purity, verified every batch.

SPECIAL OFFER ALERT: use code WELLNESS15 for -15% off all partiQlar supplements

SPECIAL OFFER ALERT: use code WELLNESS15 for -15% off all partiQlar supplements

SPECIAL OFFER ALERT: use code WELLNESS15 for -15% off all partiQlar supplements

Conclusion

Conclusion

Final Thoughts from Our Team

Our head-to-head study revealed clear trade-offs among the top quercetin supplements: some leaned on megadoses, others on ultra-pure extracts, and a few on advanced delivery technologies.

While all products showed benefits in reducing inflammation and oxidative stress to varying degrees, formulations that balanced clinically backed dosing with enhanced bioavailability stood out in both user feedback and biomarker shifts.

Armed with these insights, you can choose the quercetin option that best fits your goals, whether you prioritize simplicity, potency, or absorption.

*Some links on this site are affiliate links, meaning we may earn a small commission if you make a purchase. Our content is based on independent research and is never influenced by affiliate partnerships.

FAQ

Frequently Asked Questions

Find answers to the most common questions our readers ask about these supplements:

Is Quercetin Safe?

Is Quercetin a Blood Thinner?

Is Quercetin an Antihistamine?

Is Quercetin Good For Allergies?

Does Quercetin Cause Weight Gain?

Will Quercetin Keep Me Awake?

FAQ

Frequently Asked Questions

Find answers to the most common questions our readers ask about these supplements:

Is Quercetin Safe?

Is Quercetin a Blood Thinner?

Is Quercetin an Antihistamine?

Is Quercetin Good For Allergies?

Does Quercetin Cause Weight Gain?

Will Quercetin Keep Me Awake?

FAQ

Frequently Asked Questions

Find answers to the most common questions our readers ask about these supplements:

Is Quercetin Safe?

Is Quercetin a Blood Thinner?

Is Quercetin an Antihistamine?

Is Quercetin Good For Allergies?

Does Quercetin Cause Weight Gain?

Will Quercetin Keep Me Awake?