Chronic sleeplessness isn’t just exhausting; it’s deadly.
According to the National Sleep Foundation, each year in the U.S., drowsy drivers cause over 100,000 crashes, leading to 1,550 deaths and 71,000 injuries.
And that is not the only way insomnia and anxiety kill you.
Can’t Sleep. Can’t Relax. Can’t Function.
You’re tired all day until bedtime. Then suddenly your heart races, thoughts spiral, and sleep becomes impossible. This wired-but-exhausted state isn’t just bad luck. It’s caused by four hidden imbalances in your brain chemistry that feed off each other night after night.
First imbalance lies in GABA, your main calming neurotransmitter. GABA levels are often too low in people with anxiety or insomnia. Without enough of it, the brain stays on high alert, even when you're dead tired.
Another reason for your restlessness and anxiety is cortisol. It should drop at night, but stress keeps it elevated, triggering late-night wakeups and racing thoughts that steal deep sleep.
Furthermore, stress causes brain inflammation, which blocks deep sleep and increases next-day anxiety, fueling another restless night.
This lack of sleep and constant anxiety keep you restless constantly. The intense, anxiety-fueled fatigue produces even more inflammation and stress, closing the loop of insomnia.
How One Plant Compound Targets All Four Imbalances
Apigenin, naturally found in chamomile, parsley, and celery, doesn’t knock you out like a sleeping pill. Instead, it works with your brain to restore balance where things go off the rails during stress and sleeplessness.
It enhances GABA, the brain’s main calming signal, helping you relax without feeling groggy. It also helps lower nighttime cortisol, the stress hormone that jolts you awake at 2 a.m., keeping your system from staying stuck in “fight or flight.”
Apigenin reduces inflammation in the brain, the kind that breaks up deep sleep and fuels anxious mornings. On top of that, it protects your neurons from oxidative stress – the damage that builds up after too many restless nights and weakens your ability to relax.
The result? A brain that slows down when it should, sleeps deeper, and wakes up steadier. Apigenin doesn’t just help you feel calm, it helps you stay calm.
However, not every apigenin supplement is created equal.
About The Author – Dr. Jason Hale
Dr. Jason Hale is a veteran researcher specializing in sports and longevity supplements. As Editor-in-Chief of The Wellness Journal, he leverages his industry connections to lead in-depth product studies and deliver science-backed insights.
The Best Apigenin Supplements in 2025
Dr. Hale and his colleague, Dr. Voss, have decided to delve deep and pick out 4 best apigenin supplements on the market.
Proper & Flexible Dosage – Pure Apigenin is dosed at 100 mg per serving, which is the sweet spot to relieve sleep & anxiety issues.
Highly Pure – partiQlar’s supplement uses 98.7% pure stabilized apigenin, which is at the top end of other market offers.
Serious Value – this supplement is priced the lowest in this list, while still outperforming its competitors.
Why It’s The Best Option
PartiQlar, a highly reputable, game-changing new brand in the longevity space, took the top spot with its 50 mg, two-per-serving apigenin capsules. Each bottle includes 120 capsules, ensuring a steady 60 day supply.
Their 100 mg dose is right in the ideal range for sleep and anxiety support. It uses 98.7% pure apigenin, third-party tested for potency and quality.
High Dose – DoNotAge offers a 250 mg dose per capsule, which is more than effective, but may be wasteful for someone who’s looking for sleep benefits, not niche improvements.
No Fillers Whatsoever – This supplement purely relies on apigenin and nothing else, making it an actually healthy choice.
Very Low Value – This product comes at the price of $55 for 60 capsules, which is the highest price on this lineup.
DoNotAge offers a hefty 250 mg per capsule, well above the clinically effective range of 20-150 mg. While suitable for some, it may be more than most people need, and can’t be easily adjusted unless you skip days or split capsules.
While DoNotAge is a highly trusted brand and the product is third-party tested, the exact percentage of purity isn’t listed on the product page. That lack of detail knocks it slightly down in our transparency score.
And the value is not the greatest either. Coming at $55 for a 60 capsule bottle, it’s the most expensive product on our list. It’s also two times more expensive than partIQlar’s offering.
DoNotAge’s apigenin is a decent choice for high-dose users, but the oversized serving, lack of published purity data, and absence of absorption enhancements leave it just shy of our top pick.
Good Purity – prohealth’s product is 98% pure, and the purity claims are backed by a legitimate Certificate of Analysis.
Reasonable Value – the product comes at a price of $45 per 60 capsules, which is decent for the amount, purity, and quality.
Wasteful Dose – prohealth’s supplement provides a 500 mg dose per serving, which may be wasteful as it won’t improve the sleep & anxiety benefits any further.
Unique Blend – unlike previous apigenin supplements, this is a multi-ingredient blend for sleep, ingested after the disc is dissolved in water.
Low Transparency – this supplement blend uses chamomile extract (contains apigenin) instead of pure apigenin, but the dose of the flavonoid is unclear.
Weak Value – the price of $33 may seem low, but that’s for just 15 servings of Sleep +.
Thorne Sleep + uses chamomile extract as a natural source of apigenin, but the exact apigenin content is not disclosed. Based on typical chamomile concentrations, the dose likely falls well below the clinically effective range of 20-150 mg, making it hard to know if you’re getting enough to see real benefits.
While Thorne is a respected brand known for clean formulations, the lack of transparency around dosage and purity is a clear downside. The product also blends in other ingredients like melatonin and L-theanine, which makes it difficult to isolate what apigenin is doing, if anything.
At $33 for just 15 servings, it’s also one of the least cost-effective products in this comparison, especially considering the uncertain dose.
Thorne Sleep+ may work for people seeking a gentle, all-in-one nighttime blend, but its unclear apigenin content, low value, and lack of transparency put it firmly at the bottom of our rankings.
Not all apigenin supplements are created equal.
To actually work, they need to do more than just contain apigenin. They need to deliver the right dose, in a form your body can absorb, and with proven purity you can trust.
Why? Because if apigenin isn’t absorbed properly, it won’t calm your mind, ease stress, or help you sleep the way research shows it can. And if it's underdosed or full of fillers, you’re just wasting capsules.
That’s where PartiQlar stands out. With 100 mg of stabilized apigenin, third-party tested for 98.7% purity, it delivers clinical strength, clean ingredients, and results you can actually feel.
Apigenin is a promising natural compound for supporting deeper sleep, reducing anxiety, and promoting overall calm. Unlike harsher sleep aids, it works by gently restoring balance to key brain systems, especially when taken at the right dose and in an absorbable form.
But not all apigenin supplements are created equal. The most effective ones combine a clinically supported dose, good bioavailability, and verified purity through third-party testing.
Choosing a supplement that meets all three standards gives you the best chance of experiencing the real, lasting benefits apigenin has to offer.
*Some links on this site are affiliate links, meaning we may earn a small commission if you make a purchase. Our content is based on independent research and is never influenced by affiliate partnerships.